People usually search for this
DSIP 10mg
$80.00
≥99% purity · HPLC verified · MS confirmed
How we test →
Products will arrive in a lyophilized (powder) form for maximum stability
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino acid peptide isolated in the 1970s from sleep induction experiments, studied in research models for effects on EEG delta-wave activity and sleep architecture. Proposed mechanisms involve modulation of opioid receptors, CRH, and antioxidant pathways. Supplied as a 10mg lyophilized vial at ≥99% HPLC purity, for research use only.
Volume discounts
Auto-applied at checkout
Free shipping on orders of $200+
Compound Identity
COMPOUND NAME
Delta Sleep-Inducing Peptide
SYNONYMS
DSIP
CAS NUMBER
62568-57-4
MOLECULAR FORMULA
C47H48N12O6
MOLECULAR WEIGHT
848 g/mol
STRUCTURE
Nonapeptide
PEPTIDE SEQUENCE
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
CHEMICAL STRUCTURE
Molecular Formula: C47H48N12O6
Source: PubChem
Mechanism of Action
DSIP acts as a neuropeptide that helps regulate communication between the brain and endocrine system. It modulates key neurotransmitters such as serotonin, norepinephrine, and GABA to reduce neural excitability and promote calmness. DSIP also influences hypothalamic and pituitary signaling, helping control the release of hormones involved in sleep, stress, and recovery. Through these combined actions, DSIP supports stable sleep patterns, hormonal balance, and overall homeostasis2,3.
1
Regulate neurotransmitters – DSIP influences levels of serotonin, norepinephrine, and GABA, which are all essential for controlling mood, stress, and sleep cycles1.
2
Modulate hypothalamic and pituitary activity – DSIP interacts with the brain’s endocrine control centers, influencing the release of hormones such as ACTH, LH, and growth-related factors that play key roles in the sleep–wake cycle and physical recovery2.
3
Stabilize neuronal excitability – By reducing overactivity in the central nervous system, DSIP helps quiet neural signaling to promote relaxation and prepare the brain for deep sleep3.
4
Support homeostasis – DSIP appears to restore balance in systems that manage circadian rhythm, stress response, and energy regulation, helping maintain physiological stability even during fatigue or stress3.
Biological Activity
DSIP promotes restorative deep sleep, supports relaxation, and helps regulate hormonal balance. Studies show that DSIP enhances slow-wave sleep, calms neural activity through modulation of serotonin, norepinephrine, and GABA, and influences hypothalamic–pituitary signaling to regulate hormones such as ACTH and LH1-3.
Storage
- Store lyophilized DSIP at −20°C, protected from light and moisture. Once reconstituted, keep refrigerated (2–8°C) and use within 30 days.
Drug Categories
Peptide therapeutic; sleep-support peptide; stress-adaptation peptide
Additional Notes
- Suitable for both in vitro and in vivo research applications
Summary Table
Property
Description
CAS Number
62568-57-4
Molecular Formula
C47H48N12O6
Molecular Weight (MW)
848 g/mol
Mechanism of Action
Modulates hypothalamic and pituitary signaling; Influences serotonin, norepinephrine, GABA; Stabilizes neuronal activity
Biological Activity
Promotes restorative sleep, reduces stress response, supports endocrine regulation
Supplied Form
Lyophilized powder
Purity
≥99% (HPLC)
Storage
−20°C (dry); 2–8°C after reconstitution
Drug Categories
Peptide therapeutic; sleep-support peptide; stress-adaptation peptide
Additional Notes
For laboratory research use only
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
DSIP is a short, naturally occurring peptide that helps the body achieve restorative deep sleep, which is the stage where physical repair and hormone balance occur. DSIP works by gently influencing neurotransmitters and hormone pathways that regulate the sleep-wake cycle. It has also been shown to support stress resilience and recovery by balancing activity in the hypothalamus and pituitary gland. Because of its calming and regulatory properties, DSIP is often studied for its potential to improve rest quality, reduce sleep disruption, and promote overall homeostasis in preclinical settings1-3.
Research Highlights
Promotes Deep, Restorative Sleep: DSIP has been shown to increase the duration of slow-wave sleep (SWS) and enhance delta-wave activity in the brain, which are essential phases for recovery and hormone balance. Experimental studies demonstrated that DSIP administration led to improved sleep continuity and reduced time to sleep onset in animal models1
Regulates Key Neurotransmitters: DSIP modulates neurotransmitter systems involved in sleep and stress control, including serotonin, norepinephrine, and GABA. This regulation contributes to a calmer nervous system and improved sleep quality under stress conditions1
Balances Hormonal Activity: DSIP influences hypothalamic-pituitary signaling, particularly affecting hormones such as ACTH, LH, and growth-related peptides. This modulation helps stabilize endocrine responses during rest and stress adaptation2.
Reduces Stress and Neural Overactivity: DSIP demonstrates anti-stress and neuroprotective properties by lowering stress-induced neural excitability and supporting homeostatic balance within the central nervous system. These effects may be linked to DSIP’s ability to normalize adrenergic and GABAergic signaling in the brain3.
Pharmacokinetic Profile
Route of Administration
IV
Dosing Frequency
Once daily for 5-7 days
- Route of Administration: IV
- Dosing Frequency: Once daily for 5-7 days
- Half-Life: 2-8 minutes
Formulation & Handling
- Reconstitute in sterile saline or PBS (pH ~7.4) for in vivo/in vitro use
- Use reconstituted solution within 30 days
- Store at −20°C, protect from light and repeated freeze-thaw cycles
Clinical Trial Activity
DSIP is a research-grade compound that has been studied in laboratory and early-stage human settings but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication. DSIP is supplied strictly for laboratory research and investigational purposes only.
References
1
Graf, M. V. & Kastin, A. J. Delta sleep-inducing peptide: A review of its physiology and behavioral effects. Neurosci. Biobehav. Rev. 8, 83–93 (1984).
2
Graf, M. V. & Kastin, A. J. Delta sleep-inducing peptide (DSIP): Neurochemical and endocrine actions. Peptides 7, 1165–1187 (1986).
3
Kovalzon, V. M. & Strekalova, T. V. Delta sleep–inducing peptide (DSIP): A still unresolved riddle. J. Neurochem. 97, 303–309 (2006).
4
Schoenenberger, G. A. & Monnier, M. Delta sleep-inducing peptide (DSIP): Isolation, chemical structure, and biological properties. Brain Res. 134, 581–584 (1977).
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
Related Products
Bioregulators
Vesugen 20mg
$70.00
Read more 
Exercise
MOTS-C 40mg
$200.00
Add to cart 
GHRP
Tesamorelin 20mg
$200.00
Add to cart Related products
BPC-157 10mg
Summary Description: BPC-157 is a synthetic pentadecapeptide corresponding to a partial sequence of a protein found in human gastric juice. In preclinical models, it has demonstrated pro-angiogenic, cytoprotective, and anti-inflammatory properties1-3. BPC-157 accelerates tissue repair across tendon, ligament, muscle, and epithelial models by modulating nitric oxide pathways, upregulating VEGF and other growth factors, and promoting fibroblast migration4. Its chemical stability in gastric environments and efficacy across multiple administration routes make it a candidate for further investigation in regenerative pharmacology2.
Products will arrive in a lyophilized (powder) form for maximum stability
BPC-157/TB-500/GHK-Cu 10+10+50mg (GLOW blend 70mg)
Summary Description: The GLOW Peptide Blend is a synthetic combination of three well-characterized regenerative peptides: BPC-157, TB-500, and GHK-Cu, each with complementary mechanisms that promote cellular repair, angiogenesis, and tissue remodeling. The blend integrates the nitric oxide-mediated cytoprotective activity of BPC-157, the actin-regulating and pro-angiogenic functions of TB-500, and the copper-mediated antioxidant and anti-fibrotic properties of GHK-Cu. Collectively, this tri-peptide formulation provides a multifaceted approach to studying regeneration, inflammation resolution, and extracellular matrix restoration in preclinical models
Products will arrive in a lyophilized (powder) form for maximum stability
CJC-1295 (No DAC)/Ipamorelin Blend 5+5mg
Summary Description: The CJC-1295 (no DAC) + Ipamorelin peptide blend merges two potent growth hormone secretagogues to synergistically enhance physiologic GH pulsatility. This research-only combination stimulates both GHRH and ghrelin receptor pathways, yielding amplified and sustained GH release while maintaining endocrine feedback sensitivity.
Products will arrive in a lyophilized (powder) form for maximum stability
MOTS-C 10mg
Summary Description: MOTS-c (Mitochondrial ORF of the 12S rRNA type c) is a mitochondrial-derived peptide that plays a vital role in regulating metabolism, energy balance, and cellular stress responses. Discovered in 2015, MOTS-c functions as a signaling molecule that helps the body respond to metabolic stress by improving glucose uptake, enhancing insulin sensitivity, and promoting fat metabolism. It acts as a mitochondrial messenger that communicates with the nucleus to maintain cellular homeostasis, making it a promising target for research on metabolic health, exercise performance, and healthy aging1-4.
Products will arrive in a lyophilized (powder) form for maximum stability
TB-500 10mg
Summary Description: TB-500 is a synthetic heptapeptide analog of the actin-binding motif of thymosin ?4 (T?4), composed of the acetylated sequence Ac-LKKTETQ. This fragment conserves the principal bioactive domain associated with T?4’s regenerative activity. TB-500 has been shown to promote cell migration, angiogenesis, cytoskeletal reorganization, and anti-inflammatory signaling in preclinical models1,2. Due to its shorter sequence, TB-500 offers enhanced metabolic stability and amenability to synthetic optimization compared to the parent protein. While TB-500 is banned in competitive sports, it continues to be studied for its potential in promoting angiogenesis, tissue repair, and modulation of actin-binding proteins.
Products will arrive in a lyophilized (powder) form for maximum stability
Tesamorelin 10mg
Summary Description: Tesamorelin is a synthetic peptide analogue of growth hormone-releasing hormone (GHRH), developed for the reduction of excess abdominal fat in HIV-associated lipodystrophy. It stimulates endogenous growth hormone (GH) secretion, thereby increasing insulin-like growth factor-1 (IGF-1) levels and promoting lipolysis. Tesamorelin selectively reduces visceral adipose tissue (VAT) without significant effects on subcutaneous fat and improves body image parameters. Its stability-enhancing N-terminal modification allows for effective subcutaneous administration, and it is FDA-approved for HIV-related lipodystrophy.
Products will arrive in a lyophilized (powder) form for maximum stability
Tesamorelin 20mg
Summary Description: Tesamorelin is a synthetic peptide analogue of growth hormone-releasing hormone (GHRH), developed for the reduction of excess abdominal fat in HIV-associated lipodystrophy. It stimulates endogenous growth hormone (GH) secretion, thereby increasing insulin-like growth factor-1 (IGF-1) levels and promoting lipolysis. Tesamorelin selectively reduces visceral adipose tissue (VAT) without significant effects on subcutaneous fat and improves body image parameters. Its stability-enhancing N-terminal modification allows for effective subcutaneous administration, and it is FDA-approved for HIV-related lipodystrophy.
Products will arrive in a lyophilized (powder) form for maximum stability
Testagen 20mg
Summary Description: Testagen is a synthetic, short peptide bioregulator that targets the regulation and restoration of testicular and endocrine system functions. Developed at the St. Petersburg Institute of Bioregulation and Gerontology, it has been shown in research models to stimulate protein synthesis in testicular cells, modulate gene expression linked to steroidogenesis, influence stem cell differentiation into functional Leydig-lineage cells, and counteract age-related involution of reproductive tissues. By binding to specific DNA sequences and protecting promoter regions from methylation, Testagen helps to maintain transcriptional activity in genes involved in hormone synthesis, with potential implications for sustaining optimal testosterone production under physiological stress or aging conditions1-3.
Products will arrive in a lyophilized (powder) form for maximum stability