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NAD+ 1,000mg
$175.00
≥99% purity · HPLC verified · MS confirmed
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Products will arrive in a lyophilized (powder) form for maximum stability
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism, participating in over 500 enzymatic reactions including those mediated by sirtuins and PARPs. Tissue NAD+ levels decline with age, making it a major focus of mitochondrial and longevity research. Supplied as a 1,000mg lyophilized vial at ≥99% HPLC purity, for research use only.
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Compound Identity
COMPOUND NAME
Nicotinamide adenine dinucleotide (NAD+)
SYNONYMS
?-Nicotinamide adenine dinucleotide, NAD, Diphosphopyridine nucleotide, Coenzyme I, Nadide
MOLECULAR FORMULA
C21H27N7O14P2
MOLECULAR WEIGHT
~663.43 g/mol
STRUCTURE
Synthetic coenzyme
PEPTIDE SEQUENCE
N/A; not a peptide
CHEMICAL STRUCTURE
Molecular Formula: C21H27N7O14P2
Source: PubChem
Mechanism of Action
NAD+ functions as an essential electron carrier by cycling between oxidized (NAD+) and reduced (NADH) forms in cellular metabolism, accepting and donating electrons during glycolysis, the TCA cycle, and oxidative phosphorylation to support ATP production. Beyond its redox coenzyme activity, NAD+ serves as a substrate for sirtuins, poly(ADP-ribose) polymerases (PARPs), and other signaling enzymes that consume NAD+ during the processes of DNA repair, deacetylation, and cellular stress response. These enzymatic reactions profoundly influence energy homeostasis, repair capacity, cellular stress resistance, and gene expression
Biological Activity
NAD+ is indispensable for over 400 cellular reactions, supports mitochondrial function, and modulates antioxidant defenses. Its levels directly impact metabolic health, aging processes, DNA repair, and cellular resilience to stress1,2. NAD+ depletion, as seen in aging and certain diseases, is linked to mitochondrial dysfunction, impaired oxidative metabolism, and decreased repair capacity3,4.
Storage
- Store at -20°C or below, protected from light and moisture.
Drug Categories
Coenzymes, Redox agents, Energy metabolism intermediates
Additional Notes
NAD+ is not a peptide; it is a dinucleotide formed from nicotinamide and adenine via a pair of ribose-phosphate linkers
Summary Table
Property
Description
CAS Number
N/A; not a peptide
Molecular Formula
C21H27N7O14P2
Molecular Weight (MW)
~663.43 g/mol
Mechanism of Action
Redox cofactor and substrate for NAD+-consuming enzymes
Biological Activity
Supports ATP production, DNA repair, and cell signaling
Supplied Form
Lyophilized powder or aqueous solution
Purity
≥95% (HPLC)
Storage
–20°C (powder); 2–8°C (solution)
Drug Categories
Coenzyme, metabolic regulator, signaling substrate
Additional Notes
Non-peptide; not for human/veterinary use unless specified
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
Nicotinamide adenine dinucleotide (NAD+) is an essential molecule found in all living cells, acting at the crossroads of energy metabolism and cellular signaling. As a coenzyme, NAD+ participates in redox reactions critical for ATP production by shuttling electrons during glycolysis, the TCA cycle, and oxidative phosphorylation. Besides its cofactor role, NAD+ is also a substrate for NAD+-consuming enzymes such as sirtuins (regulators of gene expression and longevity pathways) and PARPs, which mediate DNA repair and cellular stress responses. Declines in NAD+ levels are associated with aging, metabolic dysfunction, and neurodegeneration, making NAD+ replenishment and boosting strategies of growing scientific and clinical interest. Unlike synthetic peptides or hormones, NAD+ is a naturally occurring nucleotide-derived molecule, and its manipulation can influence cell vitality, resilience, and repair capacity1,2,3.
Research Highlights
Cellular NAD+ depletion with age or disease may impair energy metabolism and increase vulnerability to stress3,4.
NAD+ supplementation and precursor therapy (e.
g., NR, NMN) potentially restore NAD+ pools and improve cellular function3.
Widely used in metabolism, aging, and neurobiology research; not for therapeutic or veterinary use unless otherwise specified.
Nicotinamide adenine dinucleotide (NAD+) serves as a central metabolic cofactor and essential substrate for a number of intracellular enzymes that regulate critical biological processes. Its mechanism of action is primarily mediated by its role as a substrate for NAD+-dependent enzymes such as the sirtuin family (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and certain ectoenzymes like CD38 and CD157. Sirtuins utilize NAD+ to catalyze deacetylation and ADP-ribosylation reactions, thereby modulating gene expression, metabolism, and stress resistance in a manner tightly linked to cellular NAD+ availability. PARPs, on the other hand, respond to DNA damage by using NAD+ to generate ADP-ribose polymers, which are essential for DNA repair and maintaining genome stability; overactivation of PARPs, such as during extensive genotoxic stress, can result in significant NAD+ depletion and subsequent compromise of cellular energy homeostasis. CD38 and CD157 act as multifunctional ectoenzymes that metabolize NAD+ to produce signaling molecules like ADP-ribose and cyclic ADP-ribose, which are involved in calcium signaling and immune regulation. In neurons, the enzyme SARM1 is rapidly activated under conditions of metabolic stress or axonal injury, triggering swift NAD+ cleavage and initiating axonal degeneration. Collectively, NAD+ exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD+ levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions1-4.
Pharmacokinetic Profile
Route of Administration
Intravenous
Dosing Frequency
Once daily
- Route of Administration: Intravenous, Oral
- Dosing Frequency: Once daily
- Half-Life: The precise plasma half-life of exogenously administered NAD+ in humans is not well characterized in the literature. However, available human studies indicate that NAD+ is rapidly cleared from the plasma for at least the first two hours of infusion, reflecting immediate tissue uptake and/or metabolism.
Formulation & Handling
- Lyophilized powder, reconstituted in sterile saline.
- Store lyophilized powder at –20?°C; Reconstituted solution cannot be stored.
Clinical Trial Activity
Trial ID
Title
Phase
Study Type
Sponsor
NCT02942888
The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition (NAD)
N/A
Interventional
The University of Texas Health Science Center at San Antonio
NCT04604704
Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 Syndrome
2
Interventional
AgelessRx
NCT03707652
Open-label Study to Assess Increasing Levels of NAD+(Nicotinamide Adenine Dinucleotide)
N/A
Interventional
Supplement Formulators, Inc
NCT03423342
Nicotinamide Riboside in Systolic Heart Failure
1/2
Interventional
University of Washington
References
1
Huang, Q., Sun, M., Li, M., Zhang, D., Han, F., Wu, J. C., Fukunaga, K., Chen, Z., & Qin, Z.-H. (2018). Combination of NAD+ and NADPH offers greater neuroprotection in ischemic stroke models by relieving metabolic stress. Molecular Neurobiology, 55, 6063–6075.
2
Grant, R., Berg, J., Mestayer, P. N., Braidy, N., Bennett, C., Broom, G. M., & Watson, K. (2019). A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6 hour intravenous infusion of NAD+. Frontiers in Aging Neuroscience, 11, 257.
3
Ying, W. (2013). Roles of NAD+, PARP-1, and sirtuins in cell death, ischemic brain injury, and synchrotron radiation X-ray-induced tissue injury. Scientifica, 2013, 691251.
4
Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metabolism, 27, 513–528.
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
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