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This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly for in vitro testing and
laboratory experimentation only. All product information available on this website is for
educational purposes only. Bodily introduction of any kind into humans or animals is
strictly forbidden by law. This product should only be handled by licensed, qualified
professionals. This product is not a drug, food, or cosmetic and may not be misbranded,
misused or mislabeled as a drug, food or cosmetic.
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Vesugen 20mg
$70.00
≥99% purity · HPLC verified · MS confirmed
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Summary Description: Vesugen is a vascular-support peptide designed to help maintain healthy blood vessels, circulation, and tissue function as the body ages. Composed of the naturally occurring amino acid sequence Lys-Glu-Asp (KED), Vesugen belongs to a class of short peptide bioregulators that help support normal cellular communication and tissue renewal. Studies suggests that Vesugen may promote healthy endothelial (vascular) cell function while supporting the body’s natural repair and regeneration processes1,2.
In addition to its vascular benefits, Vesugen has demonstrated neuroprotective and cognitive-supporting effects in preclinical research. Studies have shown that it may help preserve healthy neuronal connections, support neuroplasticity, and promote cellular pathways involved in learning, memory, and healthy brain aging2,3. By supporting both vascular and neural health, Vesugen has become an important research peptide in the fields of longevity, cardiovascular wellness, and age-related functional decline.
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Compound Identity
COMPOUND NAME
Vesugen
SYNONYMS
lysyl-glutamyl-aspartic acid
CAS NUMBER
204271-66-9
MOLECULAR FORMULA
C15H26N4O8
MOLECULAR WEIGHT
390.39 g/mol
STRUCTURE
Short Tripeptide
PEPTIDE SEQUENCE
Lys-Glu-Asp
CHEMICAL STRUCTURE
Source: PubChem
Mechanism of Action
Vesugen appears to function as a tissue-specific peptide bioregulator that supports endothelial renewal, vascular integrity, and neuroplasticity through epigenetic and regenerative signaling pathways.
Biological Activity
Vesugen demonstrates vasoprotective, regenerative, and neuroprotective activity. It increases endothelial cell proliferation, supports vascular tissue growth, restores age-related declines in Ki67 expression, and may help maintain endothelial integrity. In neurological models, Vesugen promotes neuronal differentiation, supports dendritic spine preservation, enhances neuroplasticity, and has been associated with improvements in cognitive function and memory-related processes1-3.
Storage
- Store at 2–8°C. For long-term storage, keep at -20°C. Protect from light and moisture.
Drug Categories
Amino Acids, Peptides, and Proteins; Vascular Bioregulators; Epigenetic Peptides; Neuroprotective Peptides
Additional Notes
N/A
Summary Table
Property
Description
CAS Number
204271-66-9
Molecular Formula
C15H26N4O8
Molecular Weight (MW)
390.39 g/mol
Mechanism of Action
Epigenetic regulator that may enhance MKI67 expression
Biological Activity
Supports endothelial proliferation, vascular regeneration, neuronal differentiation, dendritic spine preservation, and cognitive function
Supplied Form
Lyophilized powder
Purity>
>99%
Storage
2–8°C (short-term); -20°C (long-term). Keep dry and protected from light.
Drug Categories
Amino Acids, Peptides, and Proteins; Vascular Bioregulator; Neuroprotective Peptide
Additional Notes
N/A
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
Vesugen is a research peptide developed to support healthy vascular aging and endothelial function. Research suggests that the peptide may promote endothelial renewal, support normal vascular-wall metabolism, and encourage the expression of genes involved in cellular repair and regeneration1,2. One of Vesugen’s most distinctive characteristics is its apparent ability to support the body’s natural regenerative processes. Studies have shown that Vesugen may increase production of Ki67, a protein closely associated with healthy cell proliferation and tissue renewal. By helping maintain normal endothelial turnover, Vesugen may contribute to the long-term integrity and function of blood vessels during aging1. Beyond its cardiovascular applications, Vesugen has demonstrated promising neuroprotective properties in preclinical studies. Research suggests the peptide can support neuronal differentiation, preserve dendritic spines that are essential for memory formation, and promote healthy neuroplasticity. In Alzheimer’s disease models, Vesugen helped maintain the structural integrity of synaptic connections and supported markers of learning and memory3. These findings suggest that healthy vascular function and healthy brain function may be closely linked targets of Vesugen’s biological activity. Clinical observations have also reported improvements in measures related to cardiovascular wellness and cognitive performance when Vesugen was used as part of broader therapeutic programs. Improvements in memory, attention, reaction speed, sleep quality, and vascular-related symptoms have been described in aging populations and individuals exposed to occupational stressors. While additional research is needed, these findings continue to support interest in Vesugen as a multifunctional peptide for healthy aging and regenerative medicine research1,2.
Research Highlights
Vascular Aging: Vesugen increased endothelial cell proliferation and restored age-related declines in Ki67 expression in vascular cell cultures derived from aged animals1.
Endothelial Regeneration: In organotypic vascular tissue cultures, Vesugen stimulated tissue growth and enhanced markers associated with endothelial renewal and repair1.
Cardiovascular Health: Clinical observations reported improvements in sleep quality, cardiac rhythm disturbances, angina frequency, and lipid parameters when Vesugen was used alongside standard cardiovascular therapies1.
Cognitive Function: Oral administration of Vesugen combined with Pinealon was associated with improvements in memory, attention, thinking, reaction speed, and overall mental performance in workers exposed to hazardous occupational conditions2.
Neuronal Differentiation: Vesugen stimulated neuronal differentiation in human dental stem cells and enhanced markers of neural maturation3.
MKI67 Gene Regulation and Endothelial Cell Proliferation
- Enhances Ki67 expression: Vesugen increases expression of Ki67, a key marker of cellular proliferation that declines during vascular aging. Increased Ki67 expression has been observed in both organotypic vascular tissues and endothelial cell cultures exposed to the peptide1.
- Supports endothelial renewal: By promoting endothelial cell proliferation, Vesugen may help maintain vascular-wall integrity and support normal tissue repair processes associated with healthy aging1.
- Restores age-related regenerative capacity: Vesugen produced particularly strong effects in aged endothelial cultures, suggesting preferential support of tissues with diminished regenerative potential1.
- Promotes vascular tissue growth: Experimental studies demonstrated increased growth of vascular tissue explants following Vesugen exposure, consistent with enhanced regenerative activity1.
Pharmacokinetic Profile
Route of Administration
Subcutaneous
Half-Life
2-4 hours
- Route of Administration: subcutaneous injection
- Dosing Frequency: Varies by application and formulation; Once per day for subcutaneous injection and oral routes, multiple doses per day for sublingual
- Half-Life: 2-4 hours
- Formulation: Lyophilized powder, oral capsule, sublingual drops
Selected Clinical Trial Activity
Vesugen is a research-grade compound that has been studied in preclinical animal models but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication at this time.
References
1
Khavinson VK, Tarnovskaya SI, Linkova NS, Gutop EO, Elashkina EV. Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation in aging. Advances in Gerontology. 2015;5(4):219–224.
2
Khavinson VK, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM. Peptides tissue-specifically stimulate cell differentiation during their aging. Cell Technologies in Biology and Medicine. 2012;1:148–151.
3
Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mironova E, Erofeev A, Petukhov M. Neuroprotective effects of tripeptides—epigenetic regulators in mouse model of Alzheimer’s disease. Pharmaceuticals. 2021;14(6):515.
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
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