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Ipamorelin 5mg
$50.00
≥99% purity · HPLC verified · MS confirmed
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Products will arrive in a lyophilized (powder) form for maximum stability
Ipamorelin is a selective GHRP acting at the ghrelin receptor (GHSR-1a) to stimulate GH release with minimal effects on cortisol, prolactin, or ACTH compared to older GHRPs. This selectivity makes it the preferred GH secretagogue in research designs requiring isolated GH axis activation. Supplied as a 5mg lyophilized vial at ≥99% HPLC purity, for research use only.
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Compound Identity
COMPOUND NAME
Ipamorelin
SYNONYMS
170851-70-4, NNC-26-0161, UNII-Y9M3S784Z6
CAS NUMBER
170851-70-4
MOLECULAR FORMULA
C38H49N9O5
MOLECULAR WEIGHT
~711.86 g/mol
STRUCTURE
Synthetic pentapeptide
PEPTIDE SEQUENCE
Aib-His-D-2-Nal-D-Phe-Lys-NH?
CHEMICAL STRUCTURE
Source: PubChem
Mechanism of Action
Ipamorelin is a selective agonist of the ghrelin receptor (GHS-R1a), stimulating the release of endogenous growth hormone (GH) from the anterior pituitary. It mimics the physiologic effects of natural ghrelin without affecting cortisol, prolactin, or ACTH levels. Through targeted activation of GHS-R1a, ipamorelin initiates the GH–IGF-1 axis while preserving natural hormone pulsatility1-4.
Biological Activity
Ipamorelin stimulates a dose-dependent increase in circulating GH and subsequent rise in IGF-1. It demonstrates high in vivo potency in both animal and human models with a well-tolerated safety profile1,4. Ipamorelin shows promise as a motilin agonist in gastrointestinal contexts and has been evaluated for postoperative ileus therapy2.
Storage
- Store lyophilized powder at –20°C. Reconstituted solutions should be stored at 2–8°C and used within 30 days.
Drug Categories
Growth Hormone Secretagogue (GHS); Ghrelin Receptor Agonist; Synthetic Peptide; Research Peptide
Additional Notes
Ipamorelin is supplied for research purposes only and is not approved for therapeutic use. It has shown favorable pharmacokinetics, including reduced desensitization and absence of cortisol stimulation seen in earlier GHRPs.
Summary Table
Property
Description
CAS Number
170851-70-4
Molecular Formula
C38H49N9O5
Molecular Weight (MW)
~711.86 g/mol
Mechanism of Action
Selective ghrelin receptor agonist stimulating GH release
Biological Activity
Stimulates GH/IGF-1 axis with high specificity and no ACTH/cortisol increase
Supplied Form
Lyophilized powder
Purity
≥99% (HPLC)
Storage
–20°C (powder); 2–8°C (solution)
Drug Categories
GH secretagogue, GHS-R1a agonist
Additional Notes
No prolactin or cortisol elevation; selective GH stimulation
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
Ipamorelin is a synthetic GHS derived from the pentapeptide class of ghrelin mimetics. It acts as a potent and selective agonist at the GHS-R1a receptor. Unlike traditional GHRPs such as hexarelin and GHRP-6, ipamorelin does not stimulate ACTH, prolactin, or cortisol secretion, thereby reducing off-target hormonal side effects1.It shows strong pharmacodynamic activity, evidenced by marked GH peaks following intravenous administration in both preclinical and human models2. Clinical investigations have demonstrated its tolerability and utility in contexts like growth hormone deficiency, frailty, and gastrointestinal dysmotility. Notably, ipamorelin was evaluated in a randomized trial for management of postoperative ileus, where it showed numerically shorter recovery times for gastrointestinal function4.
Research Highlights
Selective ghrelin receptor (GHS-R1a) agonist, minimal ACTH or cortisol release1
Stimulates dose-dependent GH and IGF-1 elevation2
Exhibits high in vivo potency (ED?
? ~2.3 nmol/kg)4
Maintains physiologic GH pulsatility with minimal desensitization3
Investigated for prokinetic effects in postoperative ileus (GI-2 improvement in open-laparotomy patients)2
GHS-R1a Activation
- Selective endocrine activity: Elevates GH and IGF-1 levels without significantly increasing ACTH, cortisol, or prolactin, a limitation observed in earlier GHSs like GHRP-6 and hexarelin3.
- Gastrointestinal prokinetic effects: In clinical studies, ipamorelin accelerated recovery of upper and lower GI tract function post-surgery, likely through motilin-like agonism and central regulation2.
- Ipamorelin shows high receptor affinity with an ED?? of ~2.3 nmol/kg in pigs4
Pharmacokinetic Profile
Route of Administration
Intravenous
Dosing Frequency
Twice daily
Half-Life
2 hours
Formulation & Handling
- Lyophilized peptide powder, reconstituted in sterile PBS or water.
- Store lyophilized peptide at –20?°C; upon reconstitution, aliquot and freeze at –80?°C to avoid degradation.
- Avoid repeated freeze–thaw cycles.
Clinical Trial Activity
Trial ID
Title
Phase
Study Type
Sponsor
NCT00672074
Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus
2
Interventional
Helsinn Therapeutics (US), Inc.
NCT01280344
Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function
2
Interventional
Helsinn Therapeutics (US), Inc.
References
1
Hansen TK, et al. Highly potent growth hormone secretagogues: hybrids of NN703 and Ipamorelin. Bioorg Med Chem Lett 11 (14):1915–1918 (2001).
2
Jogaro VS et al., Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 16(9): 1412-1416 (1999).
3
Raun, K. et al. Ipamorelin, the first selective growth hormone secretagogue. Eur. J. Endocrinol. 139, 552–561 (1998).
4
Beck, DE, et al. Prospective, randomized, controlled, proof-of-concept study of the ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int. J. Colorectal Dis. 29, 1527–1534 (2014).
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
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