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BPC-157 5mg
$45.00
Products will arrive in a lyophilized (powder) form for maximum stability
BPC-157 is a synthetic 15-amino acid peptide derived from a sequence in human gastric juice, extensively studied in preclinical models for tendon, ligament, and gastrointestinal tissue repair. Proposed mechanisms include VEGFR2-mediated angiogenesis and nitric oxide pathway modulation. The 5mg lyophilized vial format suits shorter research protocols, supplied at ≥99% HPLC purity, for research use only.
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Compound Identity
COMPOUND NAME
BPC-157
SYNONYMS
Body protection compound 15, Bepecin, Bpc 15
CAS NUMBER
137525-51-0
MOLECULAR FORMULA
C62H98N16O22
MOLECULAR WEIGHT
~1419.5 g/mol
STRUCTURE
Synthetic 15-amino acid linear peptide
PEPTIDE SEQUENCE
H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
CHEMICAL STRUCTURE
Molecular Formula: C62H98N16O22
Source: PubChem
Mechanism of Action
BPC-157 modulates molecular pathways involved in tissue repair, including upregulation of VEGFR2 signaling and modulation of nitric oxide release1-3. It has been shown to influence the expression of genes involved in angiogenesis (e.g., egr-1), stabilize endothelial integrity, and facilitate the recruitment of fibroblasts to injury sites4. The peptide’s activity does not require a delivery vehicle and is preserved across oral, intraperitoneal, and topical administration routes2.
1
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Modulation
2
Enhances VEGFR2 expression and downstream angiogenesis
: BPC-157 induces rapid angiogenesis in granulation tissue via VEGFR2-associated mechanisms, promoting organized capillary formation and increased vascular density in wound regions1-3.
3
Supports endothelial cell proliferation and migration
: VEGFR2 modulation is associated with increased fibroblast activity and early connective tissue regeneration in transected ligament models4.
4
Nitric Oxide Synthase (eNOS/iNOS) Pathway Regulation
5
Stimulates NO production through eNOS/iNOS activation
: BPC-157 upregulates nitric oxide synthesis in vascular tissue and restores endothelial homeostasis, as shown in ischemic and inflammatory models3,4.
6
Restores vasomotor tone: Normalizes blood pressure in models of both pharmacologically induced hypotension and hypertension3.
7
Reduces oxidative injury: Attenuates lipid peroxidation and inflammatory oxidative stress through NO-linked mechanisms4.
Biological Activity
In vivo studies have demonstrated that BPC-157 enhances tendon and ligament healing by improving collagen organization, increasing tensile strength, and reducing histological markers of inflammation. Additionally, it exhibits protective effects against oxidative stress and has been shown to restore integrity to damaged vasculature and gastrointestinal tissues2,3.
Storage
- Store lyophilized peptide at −20°C; protect from moisture and light. Reconstituted solutions should be stored at 2–8°C and used within 30 days.
Drug Categories
Amino Acids, Peptides, and Proteins
Additional Notes
- Chemically stable in gastric juice (?24 hours)
- Water-soluble at neutral pH
- Not approved for human or veterinary use
Summary Table
Property
Description
CAS Number
137525-51-0
Molecular Formula
C62H98N16O22
Molecular Weight (MW)
~1419.5 g/mol
Mechanism of Action
Pro-angiogenic, NO-modulating, fibroblast-recruiting
Biological Activity
Enhances soft tissue repair and endothelial regeneration
Supplied Form
Lyophilized powder
Purity
≥99% (HPLC)
Storage
−20°C; reconstituted: 2–8°C
Drug Categories
Amino Acids, Peptides, and Proteins
Additional Notes
Stable across administration routes; preclinical use only
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
BPC-157 is a 15-mer synthetic peptide fragment of a protein component of human gastric juice. It has been extensively studied in animal models for its regenerative effects across multiple tissue types, including tendon, ligament, vascular endothelium, muscle, and intestinal mucosa. Mechanistically, BPC-157 appears to function through nitric oxide-mediated vasodilation, angiogenic factor regulation, and recruitment of fibroblasts and endothelial progenitor cells1-3. It also reduces leukocyte infiltration and oxidative stress markers following injury. Its ability to remain chemically intact in gastric conditions facilitates its use via oral, parenteral, or topical administration2.
Research Highlights
-Ligament and Tendon Healing
BPC-157 enhances biomechanical properties and collagen fiber organization in transected Achilles tendons and medial collateral ligaments in rodent models4.
-Angiogenesis and Endothelial Protection
The peptide promotes neovascularization by upregulating VEGFR2 and egr-1 pathways while stabilizing endothelial integrity under oxidative or inflammatory stress1,2.
-Systemic Stability and Delivery Versatility
BPC-157 retains full biological activity after exposure to gastric juice and demonstrates efficacy via multiple administration routes without requiring a carrier vehicle2.
Pharmacokinetic Profile
Route of Administration
Oral
Half-Life
24h
- Route of Administration: Intraperitoneal injection, oral, topical
- Dosing Frequency: Undetermined in humans
- Half-Life: Not clinically established; bioactive >24h in gastric environments
Formulation & Handling
- Supplied as a sterile lyophilized powder.
- Reconstitute with sterile water or saline (0.9%) under aseptic conditions.
- Do not expose to repeated freeze–thaw cycles. Protect from light and moisture.
- Use within 30 days after reconstitution and store at 2–8°C.
Clinical Trial Activity
Trial ID
Title
Phase
Study Type
Sponsor
NCT02637284
Phase I, Pilot Study in Healthy Volunteers, to Assess the Safety and Pharmacokinetics of PCO-02, Which Active Ingredient is BPC-157, a Penta-deca-peptide From Gastric Source.
1
Interventional
PharmaCotherapia d.o.o
References
1
Gjurasin, M. et al. Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury. Regul. Pept. 160, 33–41 (2010).
2
Staresinic, M. et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocyte growth. J. Orthop. Res. 21, 976–983 (2003).
3
Cerovecki, T. et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J. Orthop. Res. 28, 1155–1161 (2010).
4
Sikiric, P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology 7, 1–14 (1999)
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
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