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This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly for in vitro testing and
laboratory experimentation only. All product information available on this website is for
educational purposes only. Bodily introduction of any kind into humans or animals is
strictly forbidden by law. This product should only be handled by licensed, qualified
professionals. This product is not a drug, food, or cosmetic and may not be misbranded,
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PT-141 10mg
$50.00
≥99% purity · HPLC verified · MS confirmed
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Products will arrive in a lyophilized (powder) form for maximum stability
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide acting as a melanocortin receptor agonist, primarily at the MC4 receptor in CNS pathways. It received FDA approval in 2019 (as Vyleesi) for hypoactive sexual desire disorder, working centrally rather than peripherally. Supplied as a 10mg lyophilized vial at ≥99% HPLC purity, for research use only.
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Compound Identity
COMPOUND NAME
PT-141
SYNONYMS
Bremelanotide
CAS NUMBER
189691-06-3
MOLECULAR FORMULA
C50H68N14O10
MOLECULAR WEIGHT
~1025.2 g/mol
STRUCTURE
Cyclic heptapeptide analog
PEPTIDE SEQUENCE
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
CHEMICAL STRUCTURE
Molecular Formula: C50H68N14O10
Source: PubChem
Mechanism of Action
PT-141 exerts its effects by acting as a potent agonist at melanocortin receptors MC3 and MC4, primarily in the central nervous system. Activation of these GPCRs results in increased cAMP signaling, modulating neural pathways involved in sexual arousal and desire. Unlike PDE5 inhibitors, PT-141 does not rely on peripheral vascular changes, but instead enhances sexual motivation centrally. Its selectivity for central melanocortin receptors underlies its prosexual effects without altering hormone levels1-4.
Biological Activity
PT-141 centrally facilitates sexual arousal and desire in both sexes. In preclinical models, it increases solicitous and proceptive behaviors; in clinical studies, it enhances sexual function and satisfaction in individuals with hypoactive sexual desire disorder and certain types of erectile dysfunction. It does not significantly influence skin pigmentation or systemic endocrine function at therapeutic doses1-4.
Storage
- Store lyophilized peptide at -20°C; reconstituted solutions should be aliquoted and stored at -20°C. Avoid repeated freeze-thaw cycles.
Drug Categories
Melanocortin receptor agonist, sexual function research tool, peptide research reagent.
Additional Notes
- Does not act as a vasodilator or influence nitric oxide.
- Limited peripheral melanogenic effects compared to related peptides.
- Approved as bremelanotide for clinical use in selected jurisdictions for hypoactive sexual desire disorder (HSDD) in premenopausal women
Summary Table
Property
Description
CAS Number
189691-06-3
Molecular Formula
C50H68N14O10
Molecular Weight (MW)
~1025.2 g/mol
Mechanism of Action
Central MC3R/MC4R agonism; cAMP pathway activation; sexual arousal
Biological Activity
Enhances sexual behavior and erectile response
Supplied Form
Lyophilized powder
Purity
≥95% (HPLC)
Storage
-20°C, protect from light, avoid freeze-thaw cycles
Drug Categories
Melanocortin agonist, research peptide
Additional Notes
Laboratory use only; not for clinical or veterinary use
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
PT-141 (bremelanotide) is a synthetic cyclic peptide and potent agonist of central melanocortin receptors MC3R and MC4R. It is structurally derived from Melanotan-II, but features a modified C-terminal hydroxyl group, enhancing its selectivity for CNS targets and significantly reducing activity at MC1R1-3. Unlike traditional erectile dysfunction agents, PT-141 works through the central melanocortin pathway rather than vascular smooth muscle, making it unique for investigating sexual response and psychogenic arousal2,4. The compound induces erections and proceptive sexual behaviors in animal models and has demonstrated efficacy in clinical studies for hypoactive sexual desire disorder and sexual arousal disorders, particularly when administered intranasally or subcutaneously. PT-141 does not cause skin pigmentation or tanning. It is an invaluable research tool for probing neurobehavioral effects of melanocortin signaling and for the development of novel therapies in sexual medicine and behavioral pharmacology.
Research Highlights
Stimulates sexual arousal and erectile responses via MC3R/MC4R activation1.
Effective in both male and female animal models for proceptive sexual behaviors2,4.
Demonstrates CNS selectivity with minimal peripheral and tanning activity1-4.
Clinical studies show activity in patients with sexual arousal and desire disorders3.
Structurally related to Melanotan-II but optimized for central, not peripheral, effects1,2.
MC3 (Melanocortin 3) Receptor Agonism
- Regulates sexual behavior (CNS): Promotes neural activity in hypothalamic and limbic circuits that modulate sexual motivation and arousal1-3.
- Enhances proceptive behaviors and mating responses, especially in females2.
- Contributes to central integration of sexual cues and behavioral output4.
MC4 (Melanocortin 4) Receptor Agonism
- Potently induces penile erection and sexual desire by engaging spinal and supraspinal networks1-3.
- Increases cAMP signaling in CNS pathways, leading to rapid and reversible erectile response1-4.
- Bypasses peripheral vasodilator pathways, making its effect independent of endothelial function3.
Pharmacokinetic Profile
Route of Administration
Subcutaneous
- Route of Administration: Subcutaneous injection or intranasal spray
- Dosing Frequency: On demand
- Half-Life: 2.5 – 4 hours
Formulation & Handling
- Lyophilized powder, reconstituted in sterile saline.
- Store lyophilized powder at –20?°C.
Clinical Trial Activity
Trial ID
Title
Phase
Study Type
Sponsor
NCT03973047
Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran
1
Interventional
AMAG Pharmaceuticals, Inc.
NCT05709444
A Phase IIb, Multicenter, Open-Label, Prospective Study of Bremelanotide in Diabetic Kidney Disease (BREAKOUT)
2
Interventional
Palatin Technologies, Inc
NCT02333071
Study to Evaluate the Efficacy/?Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder (HSDD)
3
Interventional
Palatin Technologies, Inc
NCT0494306
A Phase 3, Bridging, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder (With or Without Decreased Arousal)
3
Interventional
Kwang Dong Pharmaceutical co., ltd.
References
1
Diamond, L. E., Earle, D. C., Rosen, R. C., Willett, M. S. & Molinoff, P. B. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int. J. Impot. Res. 16, 51–59 (2004).
2
Pfaus, J. G. et al. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proc. Natl Acad. Sci. USA 101, 10201–10204 (2004).
3
Diamond, L. E. et al. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist. J. Sex. Med. 3, 628–638 (2006).
4
Giuliano, F., Rossler, A. S., Clement, P., Droupy, S. & Alexandre, L. The use of telemetry technology to test the proerectile effect of Melanotan-II (MT-II) in conscious rats. Eur. Urol. 48, 145–152 (2005).
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
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