BPC-157/TB-500/GHK-Cu 10+10+50mg (GLOW blend 70mg)

Compound Name: BPC+TB500+GHK-Cu

Synonyms: GLOW blend

CAS Number: 137525-51-0 (BPC-157), 77591-33-4 (TB500), 300801-03-0 (GHK-Cu)

Molecular Formula: C₆₂H₉₈N₁₆O₂₂ (BPC-157), C₂₁₂H₃₅₀N₅₆O₇₈S (TB500), C₂₈H₄₆CuN₁₂O₈ (GHK-Cu)

Molecular Weight: ~6786.95 g/mol

Structure: Multi-peptide blend

Peptide Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (BPC-157), Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (TB500), Gly-His-Lys (GHK-Cu)

Chemical Structure:

Source: PubChem

Mechanism of Action: GLOW blend works through multiple complementary biological pathways that promote tissue repair, regeneration, and inflammation control. BPC-157 enhances angiogenesis and fibroblast activity by activating the nitric oxide and VEGF signaling pathways, which support the formation of new blood vessels and tissue healing. TB-500 promotes cellular migration and tissue remodeling by regulating actin polymerization and cytoskeletal organization, processes essential for regeneration and wound repair. GHK-Cu contributes copper-dependent antioxidant and anti-fibrotic activity by modulating inflammatory cytokines, enhancing collagen and elastin synthesis, and inhibiting TGF-β1 signaling. Together, these peptides create a synergistic effect that accelerates healing, reduces inflammation, and improves overall tissue strength and recovery^1-3.

Biological Activity: GLOW blend promotes tissue repair, regeneration, and inflammation control. It enhances collagen production, supports new blood vessel formation, reduces oxidative stress, and accelerates recovery from tissue injury. Together, these peptides act synergistically to strengthen and restore damaged tissue while improving elasticity and overall healing outcomes^1,4.

Storage:

• Store at −20°C, protect from light and moisture.
• Reconstitute in sterile saline or PBS (pH ~7.4).
• Avoid repeated freeze-thaw cycles.

Drug Categories: Regenerative peptide blend; angiogenic and anti-inflammatory complex; tissue-repair and collagen-modulating peptide

Additional Notes:

• Suitable for both in vitro and in vivo research applications

Summary Table:

Disclaimer: For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.

Detailed Product Description

GLOW blend is a synergistic combination of three naturally occurring peptides that work together to promote healing, regeneration, and cellular protection. Each component plays a distinct biological role that contributes to the blend’s overall restorative potential and anti-aging properties.

BPC-157 supports repair by stimulating angiogenesis, fibroblast migration, and collagen production. It has been shown to modulate nitric oxide and growth factor activity, which enhances blood flow and nutrient delivery to damaged tissue. These properties allow BPC-157 to accelerate the healing of muscles, tendons, ligaments, and the gastrointestinal tract while reducing inflammation¹.

TB-500, a synthetic fragment of thymosin beta-4, complements this process by regulating actin polymerization and cytoskeletal remodeling. These actions facilitate cell migration and organization at the site of injury, supporting tissue regeneration and structural recovery. TB-500 also contributes to reduced scar formation and improved flexibility during the healing process².

GHK-Cu provides copper-dependent antioxidant, anti-inflammatory, and regenerative effects. It activates antioxidant enzymes such as superoxide dismutase (SOD), promotes collagen and elastin synthesis, and suppresses fibrotic pathways by inhibiting TGF-β1 signaling. Through these effects, GHK-Cu helps restore skin integrity, strengthen connective tissue, and reduce oxidative stress at the cellular level³.

Together, the three peptides in this blend act on overlapping pathways that regulate cell migration, growth factor release, and oxidative balance. The combined effects promote faster wound closure, improved tissue strength and elasticity, and a reduction in inflammation and fibrosis. This makes the BPC+TB500+GHK-Cu blend a versatile research compound for exploring advanced tissue repair, recovery, and anti-aging applications⁴.

Research Highlights

• Stimulates Endogenous GH Release: Binds to pituitary GHS-R1a receptors and rapidly induces growth hormone secretion through calcium-mediated exocytosis².
• Improves Cardiac Function: Increases cardiac output and left ventricular function independently of GH, likely through myocardial GHS-R1a activation³.
• Reduces Bone Resorption: Lowers bone turnover markers and helps preserve bone mineral density in androgen-deficient states⁴.
• Selective Hormonal Profile: Minimal effects on IGF-I, TSH, FSH, LH; modest increases in prolactin and cortisol levels¹.

Mechanism of Action

The GLOW blend supports regeneration and repair through several complementary molecular and cellular mechanisms:

• Stimulation of Angiogenesis: BPC-157 promotes the formation of new blood vessels by activating the VEGF (vascular endothelial growth factor) and nitric oxide (NO) signaling pathways. This increases blood flow and nutrient delivery to damaged tissues, supporting faster and more complete healing¹.
• Enhancement of Fibroblast Activity: BPC-157 and TB-500 both increase fibroblast migration and proliferation, leading to improved collagen deposition and extracellular matrix organization. These effects accelerate wound closure and strengthen the structural integrity of repaired tissue^1,2.
• Regulation of Actin Polymerization: TB-500, a synthetic fragment of thymosin beta-4, regulates actin polymerization and cytoskeletal organization. This enables cell motility and tissue remodeling, key processes for regeneration and repair in muscle, tendon, and epithelial tissues².
• Copper-Dependent Antioxidant Activity: GHK-Cu provides a biologically available source of copper ions that stimulate superoxide dismutase (SOD) and other antioxidant enzymes. These effects protect cells from oxidative stress and enhance tissue recovery in injured or aging tissues³.
• Collagen and Elastin Synthesis: GHK-Cu and BPC-157 both upregulate collagen and elastin production, improving tissue elasticity, structural strength, and aesthetic recovery following injury or stress^1,3.
• Synergistic Regenerative Signaling: When combined, BPC-157, TB-500, and GHK-Cu act synergistically to stimulate angiogenesis, fibroblast activation, antioxidant protection, and inflammation resolution. The result is enhanced healing kinetics, reduced fibrosis, and improved overall tissue resilience⁴.

Pharmacokinetic Profile:

• Route of Administration: IV or SC (preclinical models)
• Dosing Frequency: Daily for 7-10 days
• Half-Life: Short, <1hr

Formulation & Handling

• Reconstitute in sterile saline for in vivo/in vitro use
• Store at −20°C, protect from light and repeated freeze-thaw cycles

• Shelf-stable for 12 months under proper conditions

Clinical Trial Activity

GLOW blend is a research-grade compound that has been studied in laboratory and early-stage human settings but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication. GLOW blend is supplied strictly for laboratory research and investigational purposes only.

References

¹Sikiric, P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology 7, 1–14 (1999)

²Maar, K. et al. Utilizing developmentally essential secreted peptides such as thymosin beta-4 to remind the adult organs of their embryonic state—new directions in anti-aging regenerative therapies. Cells 10, 1343 (2021).

³Dou, Y. et al. The potential of GHK as an anti-aging peptide. Aging Pathobiol. Ther. 2, 58–61 (2020).

⁴Freeman, D. X. The Peptide Protocols Master Bible: Evidence-Based Guide Made Simple to Next-Generation Peptides & Combos – Usage, Dosing & Cycling for Weight Loss, Muscle Growth, Longevity & Body Optimization. Benjamin Bautista Publishing (2025).