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MOTS-C 40mg
$200.00
Products will arrive in a lyophilized (powder) form for maximum stability
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within mitochondrial 12S rRNA, studied in preclinical models for metabolic regulation, glucose homeostasis, and age-related mitochondrial decline. Its primary mechanism involves AMPK pathway activation, which enhances insulin sensitivity and fatty acid oxidation. Supplied as a 40mg lyophilized vial at ≥99% HPLC purity, for research use only.
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Compound Identity
COMPOUND NAME
Mitochondrial ORF of the 12S rRNA type c
SYNONYMS
MOTS-c
CAS NUMBER
1627580-64-6
MOLECULAR FORMULA
C101H152N28O22S2
MOLECULAR WEIGHT
2174.6 g/mol
STRUCTURE
Nonapeptide
PEPTIDE SEQUENCE
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
CHEMICAL STRUCTURE
CAS Number: 1627580-64-6
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.6 g/mol
Peptide Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Source: PubChem
Mechanism of Action
energy balance and metabolic stability. It activates AMP-activated protein kinase (AMPK) by increasing intracellular AICAR levels, which enhances glucose uptake and fatty acid oxidation. Under metabolic or oxidative stress, MOTS-c translocates to the nucleus, where it regulates the expression of antioxidant and stress-response genes to protect cells from metabolic dysfunction. Through these effects, MOTS-c improves insulin sensitivity, supports mitochondrial communication, and promotes overall metabolic health1-3.
1
Mitochondrial Origin and Signaling:
MOTS-c is encoded within the mitochondrial 12S rRNA gene and functions as a mitochondrial-derived peptide that transmits signals to the nucleus to regulate cellular metabolism and stress responses1.
2
Activation of AMPK Pathway:
MOTS-c modulates the folate and methionine cycles, increasing intracellular levels of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a potent activator of AMP-activated protein kinase (AMPK). Activation of AMPK enhances glucose uptake, promotes fatty acid oxidation, and improves insulin sensitivity2.
3
Nuclear Translocation and Gene Regulation:
Under oxidative or metabolic stress, MOTS-c translocates from the cytoplasm to the nucleus, where it interacts with transcription factors and stress-response elements to regulate genes involved in metabolism, antioxidant defense, and inflammation3.
4
Antioxidant and Cytoprotective Actions:
MOTS-c enhances the expression of antioxidant and stress-response genes, reducing oxidative stress and protecting mitochondrial integrity. It suppresses inflammatory mediators and reactive oxygen species (ROS) to support long-term cellular function4.
Biological Activity
MOTS-c enhances metabolic function by improving glucose metabolism and promoting fat utilization. It increases insulin sensitivity and cellular energy efficiency through activation of the AMPK pathway. In preclinical research, MOTS-c administration improved glucose tolerance, reduced diet-induced obesity, and supported mitochondrial health. It also demonstrates antioxidant and anti-inflammatory properties that protect against metabolic and age-related cellular stress1-3.
Storage
- Store lyophilized DSIP at −20°C, protected from light and moisture. Once reconstituted, keep refrigerated (2–8°C) and use within 30 days.
Drug Categories
Mitochondrial-derived peptide; metabolic regulator; mitochondrial signaling peptide
Drug Categories: Mitochondrial-derived peptide; metabolic regulator; mitochondrial signaling peptide
Additional Notes
Summary Table
Property
Description
CAS Number
1627580-64-6
Molecular Formula
C101H152N28O22S2
Molecular Weight (MW)
2174.6 g/mol
Mechanism of Action
Activates AMPK via AICAR accumulation; regulates nuclear stress-response genes
Biological Activity
Enhances insulin sensitivity, glucose metabolism, and mitochondrial resilience
Supplied Form
Lyophilized powder
Purity
≥99% (HPLC)
Storage
−20°C (dry); 2–8°C after reconstitution
Drug Categories
Metabolic regulator; mitochondrial peptide
Additional Notes
For laboratory research use only
Disclaimer
For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.
Detailed Product Description
MOTS-c is a 16–amino acid peptide encoded within mitochondrial 12S rRNA that acts as a key regulator of metabolism and cellular stress adaptation. It functions through activation of the AMPK pathway, enhancing glucose uptake and promoting lipid oxidation. MOTS-c also serves as a mitochondrial-to-nuclear signaling molecule that regulates genes involved in oxidative stress resistance, inflammation control, and energy balance. These effects contribute to improved metabolic flexibility, reduced fat accumulation, and protection against insulin resistance and oxidative damage. Research indicates that circulating levels of MOTS-c decline with age, suggesting a potential role in promoting healthy aging and longevity1-4.
Research Highlights
Improves Glucose Metabolism:
Enhances glucose uptake and utilization through AMPK activation, improving energy efficiency1.
Reduces Fat Accumulation:
Promotes fatty acid oxidation and protects against diet-induced obesity2.
Supports Mitochondrial Function:
Regulates nuclear gene expression to improve cellular resilience and oxidative stress response3.
Enhances Exercise and Recovery:
Improves endurance and performance by increasing mitochondrial energy signaling3.
Potential Anti-Aging Effects:
Circulating MOTS-c levels decline with age; supplementation may support longevity4.
Pharmacokinetic Profile
Route of Administration
IV
Dosing Frequency
Once daily for 7-14 days
Half-Life
1hr
Pharmacokinetic Profile:
- Route of Administration: IV, SC
- Dosing Frequency: Once daily for 7-14 days
- Half-Life: <1hr
Formulation & Handling
- Reconstitute in sterile saline for in vivo/in vitro use
- Use reconstituted solution within 30 days
- Store at −20°C, protect from light and repeated freeze-thaw cycles
Clinical Trial Activity
Trial ID
Title
Phase
Study Type
Sponsor
NCT04027712
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
N/A
Observational
University of Athens
Clinical Trial Activity
References
1
Lee, C. et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 21, 443–454 (2015).
2
Lee, C., Kim, K. H. & Cohen, P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic. Biol. Med. 100, 182–187 (2016).
3
Wan, W. et al. Mitochondria-derived peptide MOTS-c: Effects and mechanisms related to stress, metabolism and aging. J. Transl. Med. 21, 36 (2023).
4
Zheng, Y., Wei, Z. & Wang, T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front. Endocrinol. 14, 1120533 (2023).
Quality & Purity
This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →
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