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5-Amino-1MQ 50mg x 25ct

Name: 5-Amino-1MQ 50mg x 25ct
SKU: 5-AMINO50MG
Price: 120 USD
Availability: InStock

$120.00

≥99% purity · HPLC verified · MS confirmed How we test →

Products will arrive in a lyophilized (powder) form for maximum stability

5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme overexpressed in the adipose tissue of obese and insulin-resistant research models. Preclinical work links NNMT inhibition to reduced fat accumulation and preserved cellular NAD+ and SAM pools. Human data are not yet available; supplied in a 50mg, 25-count format, for research use only.

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COMPOUND NAME

5-Amino-1-MQ

SYNONYMS

5-amino-1-methylquinolinium, 5MQ

CAS NUMBER

685079-15-6

MOLECULAR FORMULA

C₁₀H₁₁N₂+

MOLECULAR WEIGHT

~159.21 g/mol

STRUCTURE

Quinoline core with a methyl group at the 1-position and an amino group at the 5-position⁴.

PEPTIDE SEQUENCE

N/A; Not a peptide

CHEMICAL STRUCTURE

5-Amino-1MQ compound molecular structure

Molecular Formula: C₁₀H₁₁N₂+

Source: PubChem

5-Amino-1MQ acts as a highly selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), blocking the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl methionine (SAM) as a methyl donor. By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications. These metabolic shifts increase energy expenditure, suppress lipogenesis, and rejuvenate muscle stem cell function, providing a unique mechanism for combating obesity, fatty liver, and age-related muscle decline^1-3.

In animal models, 5-Amino-1MQ markedly reduces body weight and fat mass, improves insulin sensitivity, and reverses diet-induced hepatic steatosis and adiposity^2,3. In aged mice, it nearly doubles muscle fiber size and enhances muscle stem cell proliferation, resulting in superior muscle regeneration post-injury¹. At the cellular level, 5-Amino-1MQ promotes differentiation and metabolic reprogramming of precursor cells while being well-tolerated in repeated dosing studies⁴. It exhibits an IC₅₀ of approximately 1 μM for NNMT inhibition⁴, with favorable pharmacokinetic properties.

Store at 4°C in a dry, sterile, light-protected environment.

Experimental metabolic modulator, NNMT inhibitor, anti-obesity agent, muscle regenerative enhancer.

5-Amino-1MQ is for research use only.

Property

Description

CAS Number

685079-15-6

Molecular Formula

C10H11N2+

Molecular Weight (MW)

~159.21 g/mol

Mechanism of Action

NNMT inhibition; alters NAD⁺/SAM metabolism, boosts SIRT-1, modulates adipose, liver, & muscle pathways

Biological Activity

Reduces fat mass, normalizes liver fat, enhances muscle regeneration, stimulates energy expenditure

Supplied Form

Powder, for reconstitution

Purity

≥99% (HPLC)

Storage

4°C, dry, sterile, light-protected

Drug Categories

NNMT inhibitor; metabolic modulator; muscle recovery enhancer

Additional Notes

Not for clinical use, laboratory research only

For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.

5-Amino-1-Methylquinolinium (5-Amino-1MQ) is a first-in-class, selective NNMT inhibitor designed for research into metabolic regulation, obesity, diabetes, nonalcoholic fatty liver disease, and age-associated muscle degeneration. Preclinical studies have demonstrated that 5-Amino-1MQ effectively reprograms metabolism in key energy-regulating tissues: it counteracts obesity and associated fat accumulation, reduces pathological liver fat, and enhances the regenerative potential of aged skeletal muscle^1-3. By blocking NNMT activity, it increases critical cellular metabolites (SAM, NAD⁺) that drive downstream increases in energy expenditure and metabolic health^1-4. Further, it activates muscle stem cells, promoting tissue regeneration, and reverses insulin resistance in relevant animal models, all with good systemic tolerability^1,2. In preclinical studies, 5-Amino-1MQ provides a powerful tool to dissect the cellular and molecular consequences of NNMT inhibition. Its unique profile makes it an attractive compound for exploring the therapy of metabolic disease and muscle aging, as well as evaluating the intricate links between metabolism, epigenetics, and tissue function^1-4.

Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD⁺ and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis; in diet-induced obese mice, 5-Amino-1-MQ significantly reduces total body weight, fat mass, and adipocyte size, while improving insulin sensitivity and glucose tolerance^2,3.

Liver Health and Anti-Steatosis Activity: Reverses diet-induced hepatic steatosis by normalizing liver fat content to lean control levels, reduces liver adiposity by over 45%, improves hepatic metabolic profiles, and shifts lipid metabolism away from de novo synthesis toward enhanced fatty acid oxidation².

Muscle Regeneration and Anti-Aging Benefits: Activates senescent muscle stem cells (muSCs) in aged muscle, promoting proliferation, fusion, and regeneration; nearly doubles muscle fiber cross-sectional area and increases muscle contractile strength by ~70%, restoring regenerative function to levels comparable to youthful muscle¹.

Epigenetic and Cellular Reprogramming: By blocking NNMT-mediated methylation of nicotinamide, preserves NAD⁺ salvage pathway activity, increases SIRT-1 signaling, reduces histone deacetylation, and promotes metabolic reprogramming toward oxidative phosphorylation and glycolysis balance, supporting tissue repair and energy homeostasis^1-4.

Potently and selectively binds to the nicotinamide binding site of NNMT, blocking the methylation of nicotinamide using SAM⁴.
Elevates NAD+ and S-adenosylmethionine (SAM) levels, shifting metabolic flux toward energy expenditure and away from fat storage^1-4.
Increases SIRT-1 activity as a result of enhanced NAD+ salvage, leading to beneficial epigenetic and metabolic reprogramming, including increased oxidative phosphorylation (OXPHOS) and muscle stem cell activation^1-3.
In adipose tissue, inhibition of NNMT suppresses de novo lipogenesis, normalizes fat content, and improves insulin sensitivity^2-3.
In skeletal muscle, promotes stem cell proliferation, regeneration, and muscle fiber hypertrophy post-injury¹.

Route of Administration

Oral

Half-Life

6-8 hours

Route of Administration: Oral, Intravenous
Dosing Frequency: Once per day
Half-Life: ~6-8 hours

Soluble in saline.
Store at 4°C in a dry, sterile, light-protected environment.

5-Amino-1MQ is a research-grade compound that has been studied in laboratory settings but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication. 5-Amino-1MQ is supplied strictly for laboratory research and investigational purposes only.

Neelakantan, H., Brightwell, C. R., Graber, T. G. et al. Small molecule nicotinamide N‐methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163, 481–492 (2019).

Sampson, C. M., Dimet, A. L., Neelakantan, H. et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci. Rep. 11, 5637 (2021).

Liu, J.-R., Deng, Z.-H., Zhu, X.-J. et al. Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. BioMed Res. Int. 2021, 9924314 (2021).

Iyamu, I. D., Huang, R. Mechanisms and inhibitors of nicotinamide N-methyltransferase. RSC Med. Chem. 12, 232–243 (2021).

This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →