Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

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Vilon 20mg

Name: Vilon 20mg
Brand: Grey Research Peptides
SKU: VILON20MG
Price: 65.00 USD
Availability: InStock

$70.00

≥99% purity · HPLC verified · MS confirmed How we test →

Products will arrive in a lyophilized (powder) form for maximum stability

Vilon is a synthetic dipeptide (Lys-Glu) developed at the St. Petersburg Institute of Bioregulation, part of the short peptide bioregulator family studied for immune function, thymic activity, and longevity endpoints in Russian research models. Western replication is limited. Supplied as a 20mg lyophilized vial at ≥99% HPLC purity, for research use only.

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COMPOUND NAME

Vilon

SYNONYMS

lysylglutamic acid

CAS NUMBER

45234-02-4

MOLECULAR FORMULA

C₁₁H₂₁N₃O₅

MOLECULAR WEIGHT

~ 275.30 g/mol

STRUCTURE

Short synthetic dipeptide

PEPTIDE SEQUENCE

L-Lys-L-Glu

CHEMICAL STRUCTURE

Molecular Formula: C₁₁H₂₁N₃O₅

Source: PubChem

Vilon interacts with cellular genetic regulation systems and cell surface receptors, particularly targeting immune and epithelial cells. It modulates chromatin architecture by promoting deheterochromatinization of facultative and structural chromatin, leading to the reactivation of genes silenced during aging². Vilon also stimulates mitogen-activated signaling pathways, particularly p70S6 kinase and JNK, supports digestive enzyme activity in the small intestine, and modulates immune differentiation by influencing T-cell marker expression^1-6. Its molecular structure features potential active binding centers on the N-terminal nitrogen and the carboxyl oxygen of glutamic acid, allowing interaction with cell membranes and potentially enhancing receptor-mediated signaling³.

Vilon has demonstrated a broad spectrum of biological effects in vitro and in vivo. It upregulates digestive enzyme activities (maltase, alkaline phosphatase, glycyl-L-leucine dipeptidase) in aged intestinal tissue¹, enhances immune responses via modulation of CD5 and CD8 T-cell expression⁶, promotes chromatin decondensation and genetic activity in senescent lymphocytes², stimulates cell proliferation and wound healing⁴, and exhibits anti-inflammatory effects by reducing TNF and IL-6 production in activated macrophages⁴.

Lyophilized form: store at –20°C; reconstituted solutions stable at 2–8°C for short term (<1 week).

Immunomodulators; Geroprotectors; Regenerative peptides; Anti-inflammatory agents.

Exhibits low hydrolysis susceptibility in gastrointestinal conditions, enabling oral formulation.

Property

Description

CAS Number

45234-02-4

Molecular Formula

C11H21N3O5

Molecular Weight (MW)

~ 275.30 g/mol

Mechanism of Action

Modulates chromatin structure, activates mitogen-activated pathways, promotes enzyme activity, regulates immune differentiation

Biological Activity

Immunomodulation, anti-inflammatory, digestive enzyme enhancement, chromatin deheterochromatinization, cell proliferation support

Supplied Form

Lyophilized powder

Purity

≥99% (HPLC)

Storage

−20°C (lyophilized); 2–8°C (in solution, up to 1 week)

Drug Categories

Immunomodulators, Geroprotectors, Regenerative peptides

Additional Notes

Resistant to rapid enzymatic degradation; based on natural thymic peptide fragments

For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.

Vilon is a synthetic dipeptide designed after the amino acid sequence of thymic peptide complexes. This unique bio-regulator has been extensively investigated in experimental gerontology, immunology, and regenerative medicine. It exerts its effects through a multi-targeted mechanism, enhancing gene expression by altering chromatin structure, boosting digestive enzymes critical for nutrient absorption in aging models, and modulating immune responses at the cellular signaling level^1-6. Unlike many peptides degraded rapidly in the gastrointestinal tract, Vilon is notably resistant to enzymatic hydrolysis, allowing for potential oral use¹. Its effects extend from restoring small intestine barrier functions in aged rats¹ to increasing T-lymphocyte functional capacity and promoting anti-inflammatory cytokine profiles⁴. These qualities make it an attractive candidate for research in aging interventions, gut health restoration, immune function enhancement, and tissue regenerative therapies.

Anti-Aging and Genomic Stability: Studies show that Vilon reverses age-related chromatin condensation in lymphocytes, promotes deheterochromatinization of facultative and structural chromatin, reactivates silenced ribosomal genes, and increases sister chromatid exchange rates, contributing to improved genetic activity and cellular homeostasis in senescent cells².

Intestinal Health and Nutrient Absorption: Demonstrated to significantly enhance digestive enzyme activity, including maltase, alkaline phosphatase, and glycyl-L-leucine dipeptidase, in the epithelial and subepithelial layers of the small intestine in aged animals, Vilon restores trophic and barrier functions, optimizes nutrient absorption, and supports gut integrity¹.

Immune System Modulation: Shown to regulate thymic-derived immune cell differentiation, increasing CD5?

and CD8? T-cell populations, enhancing cytotoxic and helper T-cell function, and potentially correcting age- or stress-related immune deficiencies⁶.

Anti-Inflammatory Activity: In THP-1 monocyte/macrophage models, Vilon inhibits lipopolysaccharide-induced TNF-?

and IL-6 production, activates STAT1 phosphorylation, and reduces monocyte adhesion to inflamed endothelial cells, suggesting potent cytokine-regulating and TNF-tolerance–inducing effects⁴.

Cellular Proliferation and Wound Healing: Stimulates mitogen-activated protein kinase pathways, including p70S6 kinase and JNK, supporting protein synthesis, cell proliferation, and tissue repair; also implicated in promoting regeneration of neuronal and retinal cells^3,4.

Molecular Stability and Bioavailability: Exhibits conformational flexibility via its lysine aliphatic side chain, features active binding centers that facilitate membrane receptor interaction, and shows low susceptibility to hydrolysis under gastrointestinal conditions, making it advantageous for oral delivery and systemic bioactivity^1,3.

Promotes deheterochromatinization of both facultative and structural chromatin².
Facilitates transcriptional activation of previously silenced genes, improving cellular function in aged cells².

Activates ERK1/2, JNK, and p70S6 kinase phosphorylation in immune cells, supporting proliferation and survival signaling⁴.

Enhances activities of maltase, alkaline phosphatase, and glycyl-L-leucine dipeptidase in intestinal tissues of aged animals, aiding nutrient absorption and gut barrier integrity¹.

Influences thymic cell populations, promoting T-helper (CD4?) and cytotoxic (CD8?) differentiation patterns depending on model conditions⁶.

Salt bridge configurations between peptide nitrogen and glutamate oxygen atoms enhance binding potential at cell surface receptors³.

Route of Administration

PO (oral)

Dosing Frequency

Once daily

Half-Life

6 hours

Route of Administration: Oral (PO), Subcutaneous injection (SC)
Dosing Frequency: Once daily
Half-Life: Unknown, likely within 6 hours.

Store in tightly sealed containers, protected from light
Use only for authorized research or laboratory applications

Vilon is a research-grade compound that has been studied in laboratory settings but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication. Vilon is supplied strictly for laboratory research and investigational purposes only.

Tutel’yan, V.A., Khavinson, V.Kh. & Malinin, V.V. Physiological role of short peptides in nutrition. Bull. Exp. Biol. Med. 135, 1–5 (2003).

Khavinson, V.Kh., Lezhava, T.A. & Malinin, V.V. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull. Exp. Biol. Med. 137, 78–81 (2004)

Sevostianova, N.N. et al. Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells. Bull. Exp. Biol. Med. 154, 562–565 (2013).

Avolio, F. et al. Peptides regulating proliferative activity and inflammatory pathways in the monocyte/macrophage THP-1 cell line. Int. J. Mol. Sci. 23, 3607 (2022)

Shchegolev, B.F., Rogachevskii, I.V., Khavinson, V.Kh. et al. Molecular mechanics study of the steric structure of the dipeptides Vilon and Thymogen. Russ. J. Gen. Chem. 73, 1909–1913 (2003).

Khavinson, V.Kh., Timofeeva, N.M., Malinin, V.V., Gordova, L.A. & Nikitina, A.A. Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats. Bull. Exp. Biol. Med. 134, 562–564 (2002).

This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to ≥99% purity by HPLC with identity confirmed by mass spectrometry. A Certificate of Analysis (COA) is available for every batch. Learn about our full quality and testing process →