DSIP 10mg

Compound Name: Delta Sleep-Inducing Peptide

Synonyms: DSIP

CAS Number: 62568-57-4

Molecular Formula: C₄₇H₄₈N₁₂O₆

Molecular Weight: 848 g/mol

Structure: Nonapeptide

Peptide Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Chemical Structure:

Source: PubChem

Mechanism of Action: DSIP acts as a neuropeptide that helps regulate communication between the brain and endocrine system. It modulates key neurotransmitters such as serotonin, norepinephrine, and GABA to reduce neural excitability and promote calmness. DSIP also influences hypothalamic and pituitary signaling, helping control the release of hormones involved in sleep, stress, and recovery. Through these combined actions, DSIP supports stable sleep patterns, hormonal balance, and overall homeostasis^2,3.

Biological Activity: DSIP promotes restorative deep sleep, supports relaxation, and helps regulate hormonal balance. Studies show that DSIP enhances slow-wave sleep, calms neural activity through modulation of serotonin, norepinephrine, and GABA, and influences hypothalamic–pituitary signaling to regulate hormones such as ACTH and LH^1-3.

Storage:

• Store lyophilized DSIP at −20°C, protected from light and moisture.
• Once reconstituted, keep refrigerated (2–8°C) and use within 30 days.

Drug Categories: Peptide therapeutic; sleep-support peptide; stress-adaptation peptide

Additional Notes:

• Suitable for both in vitro and in vivo research applications

Summary Table:

Disclaimer: For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.

Detailed Product Description

DSIP is a short, naturally occurring peptide that helps the body achieve restorative deep sleep, which is the stage where physical repair and hormone balance occur. DSIP works by gently influencing neurotransmitters and hormone pathways that regulate the sleep-wake cycle. It has also been shown to support stress resilience and recovery by balancing activity in the hypothalamus and pituitary gland. Because of its calming and regulatory properties, DSIP is often studied for its potential to improve rest quality, reduce sleep disruption, and promote overall homeostasis in preclinical settings^1-3.

Research Highlights

Promotes Deep, Restorative Sleep: DSIP has been shown to increase the duration of slow-wave sleep (SWS) and enhance delta-wave activity in the brain, which are essential phases for recovery and hormone balance. Experimental studies demonstrated that DSIP administration led to improved sleep continuity and reduced time to sleep onset in animal models¹

Regulates Key Neurotransmitters: DSIP modulates neurotransmitter systems involved in sleep and stress control, including serotonin, norepinephrine, and GABA. This regulation contributes to a calmer nervous system and improved sleep quality under stress conditions¹

Balances Hormonal Activity: DSIP influences hypothalamic-pituitary signaling, particularly affecting hormones such as ACTH, LH, and growth-related peptides. This modulation helps stabilize endocrine responses during rest and stress adaptation².

Reduces Stress and Neural Overactivity: DSIP demonstrates anti-stress and neuroprotective properties by lowering stress-induced neural excitability and supporting homeostatic balance within the central nervous system. These effects may be linked to DSIP’s ability to normalize adrenergic and GABAergic signaling in the brain³.

Mechanism of Action

DSIP acts as a neuropeptide that helps the brain and body communicate during rest and recovery. Biologically, it has been shown to:

• Regulate neurotransmitters – DSIP influences levels of serotonin, norepinephrine, and GABA, which are all essential for controlling mood, stress, and sleep cycles¹.
• Modulate hypothalamic and pituitary activity – DSIP interacts with the brain’s endocrine control centers, influencing the release of hormones such as ACTH, LH, and growth-related factors that play key roles in the sleep–wake cycle and physical recovery².
• Stabilize neuronal excitability – By reducing overactivity in the central nervous system, DSIP helps quiet neural signaling to promote relaxation and prepare the brain for deep sleep³.

• Support homeostasis – DSIP appears to restore balance in systems that manage circadian rhythm, stress response, and energy regulation, helping maintain physiological stability even during fatigue or stress³.

Pharmacokinetic Profile:

• Route of Administration: IV
• Dosing Frequency: Once daily for 5-7 days
• Half-Life: 2-8 minutes

Formulation & Handling

• Reconstitute in sterile saline or PBS (pH ~7.4) for in vivo/in vitro use
• Use reconstituted solution within 30 days
• Store at −20°C, protect from light and repeated freeze-thaw cycles

Clinical Trial Activity

DSIP is a research-grade compound that has been studied in laboratory and early-stage human settings but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication. DSIP is supplied strictly for laboratory research and investigational purposes only.

References

¹Graf, M. V. & Kastin, A. J. Delta sleep-inducing peptide: A review of its physiology and behavioral effects. Neurosci. Biobehav. Rev. 8, 83–93 (1984).

²Graf, M. V. & Kastin, A. J. Delta sleep-inducing peptide (DSIP): Neurochemical and endocrine actions. Peptides 7, 1165–1187 (1986).

³Kovalzon, V. M. & Strekalova, T. V. Delta sleep–inducing peptide (DSIP): A still unresolved riddle. J. Neurochem. 97, 303–309 (2006).

⁴Schoenenberger, G. A. & Monnier, M. Delta sleep-inducing peptide (DSIP): Isolation, chemical structure, and biological properties. Brain Res. 134, 581–584 (1977).