BPC-157/TB-500/KPV/GHK-Cu 10+10+10+50mg (KLOW blend 80mg)

Compound Name: BPC+TB500+GHK-Cu+KPV

Synonyms: KLOW blend

CAS Number: 137525-51-0 (BPC-157), 77591-33-4 (TB500), 300801-03-0 (GHK-Cu), 2828433-34-5 (KPV)

Molecular Formula: C₆₂H₉₈N₁₆O₂₂ (BPC-157), C₂₁₂H₃₅₀N₅₆O₇₈S (TB500), C₂₈H₄₆CuN₁₂O₈ (GHK-Cu), C₁₈H₃₄N₄O₆ (KPV)

Molecular Weight: ~7189 g/mol

Structure: Multi-peptide blend

Peptide Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (BPC-157), Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (TB500), Gly-His-Lys (GHK-Cu), Lys-Pro-Val (KPV)

Chemical Structure:

Source: PubChem

Mechanism of Action: The KLOW blend acts on multiple cellular pathways that regulate inflammation, tissue repair, angiogenesis, and oxidative balance. BPC-157 enhances nitric oxide and VEGF signaling to promote angiogenesis and fibroblast activation. TB-500 regulates actin polymerization, enabling cell migration and cytoskeletal remodeling during tissue repair. GHK-Cu provides antioxidant and anti-fibrotic activity by modulating inflammatory cytokines, stimulating collagen synthesis, and promoting copper-dependent enzymatic repair. KPV complements these mechanisms by suppressing NF-κB activity, reducing TNF-α and IL-6 levels, and supporting epithelial integrity. Together, these peptides act synergistically to accelerate healing, reduce inflammation, and strengthen tissue resilience^1-5.

Biological Activity: KLOW exerts its biological effects through coordinated action across cellular repair, inflammation regulation, and oxidative protection pathways. BPC-157 and TB-500 promote angiogenesis and fibroblast activation, stimulating new vessel formation and collagen deposition. GHK-Cu enhances extracellular matrix remodeling, increases antioxidant enzyme activity, and reduces fibrosis. KPV reinforces these effects by suppressing pro-inflammatory cytokines and protecting epithelial and mucosal barriers from immune-mediated damage. Together, these actions accelerate wound healing, improve tissue strength and elasticity, and support homeostatic recovery following injury or inflammation^1,5.

Storage:

• Store at −20°C, protect from light and moisture.
• Reconstitute in sterile saline or PBS (pH ~7.4).
• Avoid repeated freeze-thaw cycles.

Drug Categories: Regenerative and anti-inflammatory peptide complex; angiogenic and tissue-repair blend; antioxidant and cytoprotective peptide formulation.

Additional Notes:

• Suitable for both in vitro and in vivo research applications

Summary Table:

Disclaimer: For Research Use Only. Not intended for human or veterinary use. This compound is supplied solely for laboratory and R&D purposes.

Detailed Product Description

The KLOW Peptide Blend is an advanced regenerative and anti-aging formulation that combines four synergistic peptides (BPC-157, TB-500, GHK-Cu, and KPV) to promote cellular renewal, tissue resilience, and youthful biological function. Each peptide targets a distinct aspect of the aging process, working together to restore structural integrity, reduce inflammation, and enhance cellular vitality.

BPC-157 supports systemic regeneration by stimulating angiogenesis, improving microcirculation, and promoting fibroblast migration. These actions enhance nutrient and oxygen delivery to aging tissues, encouraging collagen renewal and improved elasticity. Through modulation of nitric oxide and growth factor pathways, BPC-157 helps counteract age-related vascular decline and supports repair at the cellular level. TB-500 complements this process by regulating actin polymerization, a critical mechanism for cell motility, differentiation, and tissue remodeling. Its ability to enhance cellular communication and structural regeneration contributes to improved skin texture, muscle tone, and wound recovery. GHK-Cu provides potent anti-aging and antioxidant benefits by activating genes associated with collagen and elastin production, antioxidant defense, and cellular repair. It stimulates the synthesis of key extracellular matrix components while neutralizing reactive oxygen species, restoring firmness and reducing oxidative damage that accelerates visible and molecular aging. Finally, KPV, a C-terminal tripeptide fragment of α-MSH, introduces targeted anti-inflammatory protection. It inhibits NF-κB activation and reduces inflammatory cytokines such as TNF-α and IL-6, mitigating the chronic low-grade inflammation (“inflammaging”) that contributes to tissue breakdown and cellular senescence. KPV also supports epithelial and mucosal barrier health, helping maintain systemic resilience and reducing oxidative burden throughout the body.

Together, these peptides act on core hallmarks of aging: inflammation, oxidative stress, mitochondrial decline, and extracellular matrix degradation. The KLOW blend helps rejuvenate the cellular environment by promoting tissue regeneration, improving vascular and collagen integrity, and supporting antioxidant and immune balance. Through these mechanisms, it provides a comprehensive anti-aging and restorative foundation that enhances vitality, recovery, and structural longevity at the molecular and tissue levels^1-5.

Research Highlights

• Stimulates Angiogenesis and Fibroblast Activity: BPC-157 promotes blood vessel formation and fibroblast migration through activation of the VEGF and nitric oxide pathways, accelerating tissue regeneration and counteracting age-related vascular decline¹.
• Enhances Cellular Migration and Cytoskeletal Remodeling: TB-500 regulates actin polymerization and cytoskeletal dynamics, enabling efficient cell motility and structural repair during tissue regeneration².
• Stimulates Collagen and Elastin Synthesis: GHK-Cu upregulates genes associated with collagen, elastin, and glycosaminoglycan production, improving skin firmness and extracellular matrix integrity³.
• Protects Against Oxidative Stress: GHK-Cu activates superoxide dismutase (SOD) and other copper-dependent antioxidant enzymes, reducing reactive oxygen species and preventing oxidative damage to aging cells³.
• Reduces Inflammation and Cytokine Activity: KPV inhibits NF-κB activation and suppresses the release of TNF-α, IL-1β, and IL-6, decreasing chronic low-grade inflammation linked to aging and tissue degeneration⁴.

Mechanism of Action

The KLOW blend promotes tissue repair, inflammation control, and oxidative balance through coordinated biological mechanisms of its four active peptides:

• Promotion of Angiogenesis: BPC-157 activates vascular endothelial growth factor (VEGF) and nitric oxide (NO) pathways, stimulating new capillary formation and improving blood supply to damaged tissues. This enhances oxygenation and nutrient delivery to accelerate healing¹.
• Stimulation of Fibroblast Migration and Collagen Production: Both BPC-157 and TB-500 increase fibroblast activity and collagen synthesis, leading to stronger extracellular matrix formation and faster wound closure. These actions also support tendon and ligament repair^1,2.
• Regulation of Actin Polymerization: TB-500 regulates actin dynamics and cytoskeletal organization, enabling efficient cell migration and tissue remodeling at the site of injury. This mechanism supports regeneration across muscle, skin, and connective tissues².
• Antioxidant and Anti-Fibrotic Effects: GHK-Cu provides copper-dependent activation of superoxide dismutase (SOD) and other antioxidant enzymes that neutralize reactive oxygen species. It also suppresses TGF-alpha/Smad^2/3 signaling to reduce fibrotic tissue formation and promote balanced remodeling³.
• Modulation of Inflammatory Cytokines: KPV acts as a potent anti-inflammatory tripeptide by inhibiting nuclear factor kappa-B activation and reducing production of TNF-alpha IL-beta, and IL-6. This decreases inflammatory cell infiltration and protects surrounding tissues from secondary damage⁴.
• Epithelial Barrier Protection: KPV enhances epithelial and mucosal integrity by supporting tight-junction proteins and reducing permeability during inflammation. This helps restore homeostasis in both skin and gut tissues⁴.
• Copper-Dependent Cellular Repair: The GHK-Cu complex delivers bioavailable copper ions essential for enzymatic repair processes, including lysyl oxidase-mediated cross-linking of collagen and elastin, which improves tissue elasticity and resilience³.

Pharmacokinetic Profile:

• Route of Administration: SC (preclinical models)
• Dosing Frequency: Daily for 7-10 days
• Half-Life: Short, <1hr

Formulation & Handling

• Reconstitute in sterile saline for in vivo/in vitro use
• Store at −20°C, protect from light and repeated freeze-thaw cycles

• Shelf-stable for 12 months under proper conditions

Clinical Trial Activity

KLOW blend is a research-grade compound that has been studied in laboratory and early-stage human settings but has not undergone full clinical development. It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication. KLOW blend is supplied strictly for laboratory research and investigational purposes only.

References

¹Sikiric, P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology 7, 1–14 (1999)

²Maar, K. et al. Utilizing developmentally essential secreted peptides such as thymosin beta-4 to remind the adult organs of their embryonic state—new directions in anti-aging regenerative therapies. Cells 10, 1343 (2021).

³Dou, Y. et al. The potential of GHK as an anti-aging peptide. Aging Pathobiol. Ther. 2, 58–61 (2020).

⁴Getting, S. J., Schiöth, H. B. & Perretti, M. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) α-melanocyte-stimulating hormone peptides. J. Pharmacol. Exp. Ther. 306, 631–637 (2003).

⁵Freeman, D. X. The Peptide Protocols Master Bible: Evidence-Based Guide Made Simple to Next-Generation Peptides & Combos – Usage, Dosing & Cycling for Weight Loss, Muscle Growth, Longevity & Body Optimization. Benjamin Bautista Publishing (2025).